10 Best Vitamins for Nerve Pain Relief Caused By Peripheral or Diabetic Neuropathy

Nerve pain can make you reel in under extreme pain in the arms, legs, hands, and feet.

Other symptoms include numbness and a burning and tingling sensation. To combat nerve pain, you can take neuropathy vitamins. 

Several vitamins for nerve pain relief exist in the market, but only a few are considered the best.

We have complied compiled a list of the top 10 best neuropathy vitamins for nerve pain in the market:

1. Methylcobalamin (Methyl B12)

Methylcobalamin is a form of B12 that contains a methyl group. The B12 vitamin is a naturally occurring vitamin, which you can obtain through supplements as well as food, such as eggs, meat, fish, and milk. Long-term vitamin B12 deficiency can result in nerve damage.

If you have nerve pain, yYou will experience sensations of pins and needles in your hands and feet. You can increase your intake of vitamin B12 by taking supplements. Here are a few studies based on how methylcobalamin B12 benefits nerve pain:

Study #1:  It promotes the regeneration of damaged nerves, improves nerve conduction, and inhibits unprompted ectopic unprompted discharges of damaged primary sensory neurons. It also alleviates pain in people diagnosed with diabetic neuropathy and reduces lower back pain and neuralgia. 

Study #2:  Researchers injected vitamin B12 in seven women and four men experiencing symptoms of diabetic neuropathy. The researchers concluded that symptoms in the participants’ legs, such as burning sensations, pins and needles, and heaviness significantly improved. 

Some participants noticed an improvement in their symptoms within a few hours whereas others noticed it within one week. For some, its effects lasted for several months whereas for others, it lasted for four years. Therefore, a high concentration of vitamin B12 is highly effective and safe in reducing the diabetic neuropathy symptoms.

Study #3: In the clinical trial, 108 participants with non-insulin dependent diabetes participated. The researchers treated 62 cases with vitamin B12, giving it to them three times each week for four weeks via injection and three times each day for eight weeks via vitamin.

After 12 weeks, participants noticed a reduction in pain and numbness in their hands, legs, feet, and arms. It improved by 73% in the group who took vitamin B12 via injection and by 75% in the group who took the vitamin B12 orally. The researchers concluded that taking vitamin B12 is safe and effective to use in the treatment of diabetic neuropathy. 

2. Benfotiamine

Benfotiamine is a form of vitamin B1 or thiamine. Its primary function is to convert food to energy, but it also possesses several different neurological benefits. These include maintaining focus and attention. The following studies support vitamin B1’s role in improving the symptoms of nerve pain:

Study #1:  Researchers, in a 6-week trial, divided 36 participants with painful diabetic neuropathy into three groups. They treated each group with vitamin B1 and noted a drastic improvement in their symptoms in the third week of therapy. They concluded that vitamin B1, whether given in small or large doses, is effective in the treatment of nerve pain.

Study #2:  Researchers divided participants into two groups, treating one with vitamin B1 in higher doses and the other in lower doses. After 6 weeks, they stated that higher doses of vitamin B1 at higher doses were as more effective in treating nerve pain than in lower doses and only improved with time.

3. Alpha Lipoic Acid (ALA)

Magnesium can benefit people suffering from nerve pain is one of the most potent antioxidants, which your body creates naturally. There are several studies that state that taking ALA can reduce neuropathy. Refer to these studies:

Study #1:  Researchers provideds high doses of ALA to participants with diabetic neuropathy for three months. They concluded that it improved both nerve conduction velocity and clinical manifestations, thus making it a safe and effective option to for treating nerve pain.

Study #2:  In the study, the researchers provided participants with ALA, half intravenously and the other half ve orally.  The researchers stated that intravenous ALA led to a clinical and statistical short-term improvement in nerve pain while oral administration led to a statistical but not clinical improvement.

4. Gamma-Linolenic Acid (GLA)

Gamma-Linolenic Acid or GLA is an omega-6 fatty acid and is one of the two primary types of essential fatty acids.  Your body utilizes these essential fatty acids to create a range of leukotrienes and prostaglandins

These substances influence pain and inflammation and taking GLA can create a balance by creating more leukotrienes and prostaglandins that reduce pain and inflammation. The following evidence suggests that taking GLA can reduce nerve pain:

Study #1: GLA reduced nerve pain in human trials.

Study #2: The researchers treated 111 participants with mild diabetic neuropathy for more than a year. They provided them with a 420 mg dose of GLA each day and examined their hands, feet, arms, and legs and concluded that GLA has beneficial effects on treating and reducing the symptoms associated with nerve pain.

5. Acetyl L Carnitine (ALC)

Acetyl L Carnitine is made from L-carnitine in your body and you can take it to treat nerve pain caused by diabetes, antiviral medications, and peripheral neuropathy. The following are studies on Acetyl L Carnitine and its effect on nerve pain:

Study #1:  Researchers divided participants into two groups, giving one group a 500 mg dose of ACL and the other group a dose of 1,000 mg of ALC per day. They concluded that ALA is effective in alleviating the symptoms of diabetic neuropathy, especially pain, and improves both vibration perception and nerve fiber regeneration.

Study #2:   Researchers performed a meta-analysis of four randomized controlled clinical trials. They measured the reduction in pain in people with diabetic neuropathy. They concluded that ALC as a safe and effective treatment in people experiencing severe nerve pain. 

The authors also said that more clinical trials need to be performed to assess the optimal dose of ALC and the duration it should be given to participants to induce a therapeutic effect.

6. Magnesium

Magnesium can benefit people suffering from nerve pain due to peripheral neuropathy. Magnesium deficiency in people with diabetes can increase the risk of developing nerve pain. They can take magnesium supplements to prevent the medical condition from progressing. Here are a few studies that show the benefits of taking magnesium for nerve pain:

Study #1:   Researchers performed a randomized clinical trial to observe the effects of nerve pain. They concluded that even though there was not a drastic reduction in the pain they experienced, it did decrease the frequency of pain they experienced, which in return, improved their emotional well-being.

Study #2:   Researchers concluded that taking magnesium increased the recovery speed of the neurological function and increased the regeneration of damaged nerves in mice suffering from a nerve injury.

7. Zinc

Zinc serves several purposes, such as aiding the neurological function, growth and development, immune system response, wound healing, and gene expression. Here a few studies that have studied the effects of zinc in reducing nerve pain:

Study #1:  Researchers gave zinc to rats with nerve pain due to diabetes. They gave the diabetic rats zinc supplements for 8 weeks. They concluded that zinc exhibited a protective effect against nerve damage by reducing oxidative stress and stimulating metallothionein synthesis.

Study #2:  The researchers performed a double-blind randomized study. They performed the study for six weeks. They gave zinc supplements to people with nerve pain due to diabetes. They concluded that zinc supplements can could achieve improved glycemic control and reduce the severity of nerve pain.

8. Coenzyme Q10 (CoQ10)

Coenzyme Q10 or CoQ10 is utilized by your body to convert food into adenosine triphosphate or ATP, which your body uses for energy. People with neuropathy can take CoQ10 to can improve nerve function and alleviate the symptoms of the medical condition by 50%. The following studies observed the influence of CoQ10 in reducing nerve pain:

Study #1:  Researchers provided 8 months old mice with diabetes with CoQ10. The mice suffered from a loss of sensation, reduction in mechanical hyperalgesia, hypoalgesia, sciatic nerve conduction velocity, and cold allodynia. They treated the mice with CoQ10 and concluded that if given CoQ10 at an earlier stage can decrease the risk of developing peripheral neuropathy.

Study #2:  The research concluded that supplementing a person’s diet with CoQ10 can decrease nerve pain if it is prescribed after a person undergoes the initial therapy for peripheral neuropathy.

9. Vitamin D

Vitamin D deficiency is prevalent in people with diabetic peripheral neuropathy. A reduction in vitamin D can increase the level of pain experienced in diabetic peripheral neuropathy. The following studies show the correlation between vitamin D and the a decrease in nerve pain:

Study #1:  Researchers studied 143 participants with type- 2 diabetes between the ages of 48 and 52. 58 participants showed signs of vitamin D deficiency.  The researchers gave the participants an intramuscular dose of vitamin D (600,000 IU). They noted that a single dose of vitamin D reduced the symptoms of peripheral neuropathy. 

Study #2:  The study examined the correlation between low levels of vitamin D with diabetic peripheral neuropathy. The researchers concluded that it is possible that vitamin D can decrease the chronic symptoms of diabetic peripheral neuropathy.

10. Inositol

Inositol is synthesized in the body and is not part of the family of vitamin B complex as it was thought previously. Inositol can aid with the conduction of nerve signals and can alleviate nerve pain. Taking inositol supplements can improve cell membrane health and conduct nerve signals.

Study #1:  Researchers concluded that a diet rich in inositol can have a positive effect in on the reduction of nerve pain in people with nerve pain and added that inositol does not have side effects.

Study #2:  In the study, researchers gave 7 participants with diabetic peripheral neuropathy with 500 mg of inositol two times each day for two weeks. They concluded that inositol positively effected the sural, popliteal, and sural nerves by 160%, 40%, and 76%, respectively. Therefore, stating that taking inositol supplements may benefit a person diagnosed with diabetic neuropathy. 

Final Thoughts

If you suffer from nerve pain and need to Benfotiamine is a form of vitamin B1 or thiamine with your diet with a vitamin that can decrease the intensity of nerve pain, you should consider taking one or more of these vitamins. Before you do, you should discuss it with your medical practitioner first.